Upper Darby High School's Wall of Fame committee recognizes individuals who have become leaders in their industries. Wall of Fame members are noted by WoF after their information.
- Lloyd Alexander; Class of 1940: Fantasy writer, author of the books forming the basis for Disney's The Black Cauldron. WoF
- Keith Andes; Class of 1938: Broadway and film actor.
- Peter Bernardino; Class of 1936: National Wrestling Hall-of-famer WoF
- Dick Botticelli; Class of 1942: Under the name Dick Richards: drummer for Bill Haley & His Comets 1953–55, singer for The Jodi mars 1955–1958, singer/drummer for The Comets 1989–present; actor WoF
- Mario J. Civera, Jr.; Class of 1965: Member of the Pennsylvania House of Representatives WoF
- Jim Croce; Class of 1960: Singer-songwriter, one Number 1 album. WoF first Wall of Famer
- Mark Cronin; Class of 1982: Creator and producer of many VH1 shows including, Flavor of Love, Rock of Love, Rock of Love Charm School, I Love Money, The Surreal Life, etc. WoF
- Heather Donahue; Class of 1991: Star of The Blair Witch Project and Taken.
- Tina Fey; Class of 1988: Senior writer, Saturday Night Live. Scriptwriter and co-star, Mean Girls and the TV show 30 Rock. Notable player in the 2008 presidential campaign because of her impersonation of Republican Vice-Presidential candidate Sarah Palin. WoF
- D'or Fischer, professional basketball player
- Kermit Gordon; Class of 1933: Former trustee of the Ford Foundation and President of the Brookings Institution WoF
- Cindy Dee Holmes; Class of 1966: Author, Red Balloons Fly High, Slaying the Virus Villains, and a A Third Serving of Chicken Soup for the Soul WoF
- James D. Houston; Class of 1977: Received a 1991 Academy Award for design and development of Disney's CAPS (Computer Animation Production System) and a 2007 Academy Award for development of a film archiving and restoration system. WoF
- Nick Jushchyshyn; Class of 1988: Visual effects artist on feature films including Curious Case of Benjamin Button and The Road.
- Bob Lloyd; Class of 1963; NCAA First Team All-American and then American Basketball Association player
- F. Joseph Loeper; Class of 1962: Former majority leader of the Pennsylvania Senate WoF
- David MacAdam; Class of 1928: Discoverer of MacAdam ellipses; former head of image structure at Eastman Kodak Research Laboratory, former President of Optical Society of America
- Shannon Meehan; Class of 2001: Iraq War hero, author, disabled Veterans activist. WoF
- Hwang Young Min (Tim (singer)); Class of 2000: Korean-American Pop Artist
- James J. Morris; Class of 1966: Vice President, Engineering and Manufacturing for Boeing Commercial Airplanes
- Edward Murphy; Class of 1953: Hollywood director ("Raw Force" 1982; "Heated Vengeance" 1985)
- Terrence J. Nolen; Class of 1981: Artistic director of the Arden Theatre Company (Philadelphia)
- Dorothy Germain Porter; Class of 1943: Amateur golfer, winner – U.S. Women's Amateur in 1949, U.S. Senior Women's Amateur in 1977, 1980, 1981, 1983. WoF
- Jack Ramsay; Class of 1942: NBA coach, Naismith Memorial Basketball Hall of Fame 1992, seventh-winningest coach in NBA history WoF
- Todd Rucci; Class of 1988: Played for the New England Patriots
- Todd Rundgren; Class of 1966: Musician and award-winning record producer
- Alvin Sargent; Class of 1945: Two-time Academy Award winner for screenplays (Julia and Ordinary People). WoF
- Lou Schonder; Class of 1977: Director and Founder, earthMed (2007). Director of Medical Programs, Project Open Hearts (2006–07). President, Philadelphia Area Medical Instrumentation Association (1993–94). Association for the Advancement of Medical Instrumentation (AAMI)/American College of Clinical Engineering (ACCE) Robert L. Morris Humanitarian Award (2007).
- Jerome Socolovsky; Class of 1982: journalist, radio correspondent formerly with National Public Radio NPR and currently with Voice of America (VOA).
- "Uncle" Marty Stern; Class of 1954: Coach, best known for his success with the women's cross country team at Villanova. WoF
- Sterling Voltz; Class of 1939: Research Scientist, Missile and Space Division of General Electric, listed in American Men of Science, American Men and Women of Science, Who’s Who in Science and Engineering, and Who’s Who in the World WoF
- George Wackenhut; Class of 1937: Founder of Wackenhut Corp, major security contractor WoF
- Floyd Wedderburn; Class of 1994: Played for the Seattle Seahawks
- Carolyn "Bunny" Welsh; Class of 1961: Sheriff of Chester County, Pennsylvania. One of only 22 female sheriffs in the US WoF
- William Wharton; Class of 1943: Writer, best known for his first novel Birdy, which was also successful as a film. WoF